Synthetic Route of 35344-95-7,Some common heterocyclic compound, 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, molecular formula is C4H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a stirring solution of 6bromonicotinaldehyde (1.25 g, 6.72 mmol) in DMF (10 mL) was added K2CO3 (2.32 g, 16.80 mmol) and 4methyl1Himidazole (0.55 g, 6.72 mmol). The resulting mixture was heated at 100 ¡ãC for 1 h then cooled to ambient temperature. The reaction was poured into ice water (30 mL) and extracted with ethyl acetate (2 x 75 mL). The combined organic layers were washed with brine (50 mL), dried over sodium sulfate and evaporated under reduced pressure. The residue was purified by flash chromatography (Redisep40 g, 0100percent EtOAc/nHexane)) to obtain Intermediate 20 (0.50 g, 39.70percent) as light brown solid.1H NMR (300 MHz, DMSOd6) G ppm 2.50 (s, 3 H), 7.76 (s, 1 H), 7.95 (dd, J = 6.00, 1.20 Hz, 1 H), 8.39 (dd, J = 6.60, 1.80 Hz, 1 H), 8.55 (d, 1.20 Hz, 1 H), 8.99 (s, 1 H), 10.08 (s, 1 H), LCMS:(MethodH) retention time :1.03 min, [M+1]: 188.0.
The synthetic route of 35344-95-7 has been constantly updated, and we look forward to future research findings.