In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 5-Methyl-1H-pyrazol-3-amine
Sodium hydride (60percent dispersion in ? mineral oil, 0.81 g, 33.96 mmol) was added slowly to a stirred suspension of ? 5-methyl-1H-pyrazol-3-amine (3.00 g, 30.90 mmol) in ? tetrahydrofuran (150 mL) at 0 ¡ãC. The mixture was stirred for 30 minutes, then ? di-tert-butyl dicarbonate (7.40 g, 33.96 mmol) was added to the reaction. The mixture was stirred and warmed to room temperature. After 2 hours, saturated ? aqueous sodium hydrogencarbonate solution was added to the reaction and the mixture was extracted with chloroform. The organic layer was washed with brine, dried (Na2SO4) and evaporated. Followed by purification of the crude product by flash chromatography (2.44 g, 40percent).LRMS (m/z): 198 (M+1)+.1 H NMR (400 MHz, METHANOL-d4) delta ppm 1.61 (s, 9 H) 2.10 (s, 3 H) 4.85 (s, 2 H) 5.24 (s, 1 H)
The synthetic route of 31230-17-8 has been constantly updated, and we look forward to future research findings.