Reference of 180207-57-2, A common heterocyclic compound, 180207-57-2, name is 2-(1H-Pyrazol-4-yl)ethanol, molecular formula is C5H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Reference Example 22: 2-[1-(5-Fluoropyridin-2-yl)-1H-pyrazol-4-yl]ethanol To a solution of 2-(1H-pyrazol-4-yl)ethanol (1.0 g, 8.9 mmol) and 2,5-difluoropyridine (0.89 mL, 9.8 mmol) in acetonitrile (45 mL), Cs2CO3 (9.7 g, 17.8 mmol) was added, and the resulting mixture was stirred for 3 hours at 80C. The reaction mixture was allowed to cool, then water was added thereto, followed by extraction with EtOAc. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over Na2SO4, then the drying agent was filtered off, and then the solvent was distilled off under reduced pressure. The obtained residue was purified by column chromatography (HP-Sil 25 g, hexane/EtOAc = 90/10 to 30/70) to obtain the title compound (0.63 g) (colorless solid). MS (ESI pos.) m/z: 208 [M+H]+
The synthetic route of 180207-57-2 has been constantly updated, and we look forward to future research findings.