These common heterocyclic compound, 25016-11-9, name is 1-Methyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Methyl-1H-pyrazole-4-carbaldehyde
General procedure: A mixture of appropriate aldehyde (10 mmol) from the list a-t, compound 4 (10 mmol), ZnO Nano particles (2 mmol) and ethanol (25 mL) was stirred at rt for 30 min to 1 h. After completion of reaction (monitored by TLC), the reaction mixture was filtered through a nanofiltration membrane (Make: Synder, Model: NFS 100-250Da). The filtrate was evaporated under reduced pressure and dried to obtain crude product 5a-t which was further purified by recrystallization in ethanol to afford pure compounds.
The synthetic route of 1-Methyl-1H-pyrazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.