In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6645-69-8 as follows. COA of Formula: C5H5N3O4
To a solution of 2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)aniline(8; 0.14 g,0.58 mmol,1 equiv.)and 2-(4-nitro-lH-pyrazol-1-yl)acetic acid(3b- ; 0.10 g,0.58 mmol,1.0 equiv.)in pyridine(5 ml)slowly added P0C13 (0.49 g,3.21 mmol,7.8 equiv.)at 0 C. The reaction was further maintained at the same temperature for 15 minutes. The reaction mixture was then quenched into ice and the product was then extracted with ethyl acetate. The combined organic layer was washed by IN HC1 solution followed by brine solution,dried over sodium sulfate,filtered and concentrated under reduced pressure to get crude product. The crude product thus obtained was purified by column chromatography on silica gel with a mixture of ethyl acetate and n-hexane as an eluent to obtain 0.038 g of the title compound 1A-1-16 as off white solid.NMR(CDCI3): 8.42(d,J = 7.6 Hz,1H),8.32(s,1H),8.31(bs, 1H),8.24(s,1H),6.99(d,J = 11.6 Hz,1H),5.00(s,2H),3.36(q,J = 9.6 Hz,2H),2.43(s,3H).
According to the analysis of related databases, 6645-69-8, the application of this compound in the production field has become more and more popular.