64517-88-0, name is 1,3-Dimethyl-1H-pyrazol-4-amine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 1,3-Dimethyl-1H-pyrazol-4-amine
Example 1.012- [ [5-C yano-2- [(1 ,3-dimethylpyrazol-4-yl)aminol -4-pyridyll amino I -N-methyl- benzamide 2-[(2-Chloro-5-cyanopyridin-4-yl)amino]-N-methylbenzamide (200 mg, 0.70 mmol), palladium(II) acetate (12.53 mg, 0.06 mmol), l,3-dimethylpyrazol-4-amine (155 mg, 1.40 mmol), 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (48.4 mg, 0.08 mmol) and cesium carbonate (273 mg, 0.84 mmol) were suspended in dioxane (5 mL). The mixture was purged for 5 minutes with nitrogen and then heated at 900C for 24 hours. The mixture was allowed to cool to room temperature and then loaded onto an SCX column. The mixture was eluted first with MeOH and then with a solution of 7N NH3 in MeOH. Fractions containing product were combined and then evaporated. The residue was purified by preparative HPLC and fractions containing product were combined and evaporated to afford example 1.01 (126 mg, 50% yield); 1U NMR spectrum: (300 MHz, DMSO) delta 2.12 (3H, s), 2.84 (3H, d), 3.77 (3H, s), 6.60 (IH, s), 7.21 (IH, ddd), 7.58 (2H, d), 7.79 (IH, d),
The synthetic route of 64517-88-0 has been constantly updated, and we look forward to future research findings.