Electric Literature of 132712-71-1, A common heterocyclic compound, 132712-71-1, name is 3-Methyl-1H-pyrazol-5-ol, molecular formula is C4H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound (M-32) (1.00 g, 10.2 mmol)And potassium carbonate (4.23 g, 30.6 mmol)Was dissolved in acetonitrile (30 mL)1,4-dibromobutane (2.64 g, 12.2 mmol) and the mixture was stirred for 12 hours at 50 C.. Thereafter, water was added,And extracted with ethyl acetate.After drying the organic layer with anhydrous sodium sulfate,After filtration, the solvent was distilled off under reduced pressure condition.The residue was purified by silica gel column chromatography (n-hexane: ethyl acetate)To obtain a compound (M-34).
The synthetic route of 132712-71-1 has been constantly updated, and we look forward to future research findings.