Application of 863548-52-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 863548-52-1, name is (1-Methyl-1H-pyrazol-5-yl)methanamine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a solution of C-(2-methyl-2H-pyrazol-3-yl)-methylamine (78 mg, 0.7 mmol) in dioxane (30 mL) was added 4-phenoxycarbonylamino-benzoic acid ethyl ester (200 mg, 0.7 mmol) and TEA (213 mg, 2.1 mmol). After stirred at 90 C overnight, the reaction mixture was concentrated in vacuum. The residue was purified by pre-HPLC to afford ethyl 4-(3-((1-methyl-1H-pyrazol-5- yl)methyl)ureido)benzoate (45 mg, 21%) as a white solid. ?H NIVIR (400 IVIHz, CD3OD): oe = 7.91 (d, J= 8.8 Hz, 2H), 7.49 (d, J= 8.4 Hz, 2H), 7.36 (d, J= 1.6 Hz, 1H), 6.24 (d, J= 1.6 Hz, 1H), 4.47 (s, 2H), 4.32 (q, J= 7.2 Hz, 2H), 3.87 (s, 3H), 1.37 (t, J= 7.2 Hz, 3H). MS: m/z 303.0 (M+H).
The synthetic route of (1-Methyl-1H-pyrazol-5-yl)methanamine has been constantly updated, and we look forward to future research findings.