Adding a certain compound to certain chemical reactions, such as: 1089212-38-3, name is 4-Bromo-3-(difluoromethyl)-1-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1089212-38-3, HPLC of Formula: C5H5BrF2N2
25. Preparation of N-(9-isopropylbenzonorbornen-5-yl)-3-difluoromethyl-1-methyl-pyrazole-4-carboxamide in the presence of 2,2-dimethyl-1,3-bis(diphenylphosphino)propane (Pepstar)A solution of Pd(PhCN)2Cl2 (0.0375 mmol) and Pepstar (0.1125 mmol) in dimethyl-formamide (DMF, 10 ml) was stirred at room temperature for 30 minutes. The solution comprising the pre-formed catalyst was transferred into an inertized autoclave. In a CO countercurrent, diazabicyclodecene (DBU, 16.5 mmol) and solutions of 3-difluoro-methyl-1-methyl-4-bromopryazole (16.5 mmol) and 5-amino-9-isopropylbenzo-norbornene (15 mmol) in DMF (in each case 25 ml) were added to the solution of the catalyst in the autoclave. The reaction mixture was stirred at 150 C. and a CO pressure of 15 bar for 24 h.The conversion based on the bromopyrazole was almost quantitative, at a selectivity of 38%. The composition of the reaction discharge was, according to GC analysis, as follows: DMF 73.8 area %, bromopyrazole 0.02 area %, DBU 8.2 area %, amino-isopropylbenzonorbornene 7.1 area % and N-(9-isopropylbenzonorbornen-5-yl)-3-difluoromethyl-1-methylpyrazole-4-carboxamide 4.08 area %.Work-up was carried out as described in example 2.i), giving an isolated yield of N-(9-isopropylbenzonorbornen-5-yl)-3-difluoromethyl-1-methylpyrazole-4-carboxamide of 38%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-(difluoromethyl)-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.