Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2820-37-3, name is 3,4-Dimethyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Safety of 3,4-Dimethyl-1H-pyrazole
5 will weigh 100mg, 0.23mmolThe pentachloroene was placed in a 25 mL two-necked flask.Drum nitrogen evacuation was repeated 3 times to obtain an anhydrous and oxygen-free reaction system.Then 7 mL of N,N-dimethylformamide was added as a reaction solvent.The reaction device is then placed in a sonicator at room temperature for 2hThe decachloromaleene is fully dispersed in N,N-dimethylformamide,At the same time weighed 68mg,2.84mmol, 20 equivalent mass fraction of 60%The sodium hydride was placed in a 25 mL two-necked flask.Drum nitrogen evacuation repeat 3In the same manner, an anhydrous and oxygen-free reaction system was obtained.Then 8 mL of N,N-dimethylformamide was added as a reaction solvent.Stir 0.5 h so that sodium hydride is fully dispersed in the solvent.Then use a syringe to extract 453mg,20 equivalents of 3,4-dimethylpyrazole are slowly injected into dispersed sodium hydride N,N-dimethylformamide.Then there are a lot of bubbles in the solution,Stirred for 0.5 h to give a clear orange solution.Then slowly add this clear orange solutionAfter ten bowl chloride ultrasound ene reaction flask,It can be seen that the color of the solution quickly turns dark green and slowly approaches blackThe reaction system was reacted overnight at 25C.After the reaction is over,Add a small amount of water slowly to quench the reaction.Then it is extracted with dichloromethane and washed continuously until the color in the aqueous phase is colorless.Then all the organic phases were collected, spin-dried and passed through a silica gel column.The light yellow ribbon is the target molecule3,4-Dimethylpyrazoleene bowlene compound, 4.4 mg,The yield was 30%
The synthetic route of 2820-37-3 has been constantly updated, and we look forward to future research findings.