Related Products of 578008-32-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 578008-32-9, name is tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.
Step 2: Synthesis of tert-Butyl 3-((4-(4-methoxy-4-(methoxycarbonyl)cyclohexyl)-6- methylpyrimidin-2-yl)amino)-5-methyl-lH-pyrazole-l -carboxylate. (0298) Methyl 4-(2-chloro-6-methylpyrimidin-4-yl)- 1-methoxycyclohexane- 1-carboxylate (70.5 mg, 0.236 mmol), tert-butyl 3-amino-5-methyl-lH-pyrazole-l-carboxylate (69.8 mg, 0.354 mmol), di-tert-butyl(2′,4′,6′-triisopropyl-[l, -biphenyl]-2-yl)phosphine (20.0 mg, 0.2 equiv.), Pd2(dba)3 (21.6 mg, 0.1 equiv.), and potassium acetate (70 mg, 0.71 mmol) were combined in a vial under nitrogen and 0.98 mL dioxane was added. The reaction mixture was heated to 115 C for 2 h, then cooled to ambient temperature. The reaction mixture was diluted with EtOAc, filtered through celite, concentrated onto silica gel, and the resulting residue was purified by flash-column chromatography on silica gel (gradient elution, 0 to 100% ethyl acetate-hexanes) to give tert-butyl 3-((4-(4-methoxy-4-(methoxycarbonyl)cyclohexyl)-6-methylpyrimidin-2- yl)amino)-5-methyl-lH-pyrazole-l-carboxylate (48 mg, 44%) as a yellow oil. MS (ES+) C23H33N505 requires: 459, found: 460 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate. I believe this compound will play a more active role in future production and life.