Synthetic Route of 3920-50-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3920-50-1, name is Pyrazole-3-carboxaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a suspension of 0.60 g (6.24 mmol, 1.0 eq.) of 1H-pyrazole-3-carbaldehyde in 12 mL ofmethylene chloride at -40 ¡ãC under a nitrogen atmosphere was added 1.63 mL (9.37 mmol,1.5 eq.) of 1VN-diisopropylethyl amine, followed by 1.66 mL (9.37 mmol, 1.5 eq.) of[2- (chloromethoxy)ethyl]trimethylsilane. The mixture was allowed to warm to room temperature and stirred for 16 h. The reaction mixture was then diluted with 20 mL brine, and extracted with 3 x 30 mL of methylene chloride. The combined organic extracts were dried(Na2SO4), filtered, and the solvent was removed in vacuo. The residue was absorbed on CELITE? and purified by flash chromatography (Si02, eluting with a gradient of 0-30percent ethyl acetate/hexanes) to provide 1 g (66percent) of a mixture of 1-((2-(trimethylsilyl)ethoxy)methyl)- 1H-pyrazole-5 -carbaldehyde and 1 -((2-(trimethyl silyl)ethoxy)methyl)- 1H-pyrazole-3 – carbaldehyde in an approximately 1:1 ratio.
The synthetic route of Pyrazole-3-carboxaldehyde has been constantly updated, and we look forward to future research findings.