Synthetic Route of 127107-23-7,Some common heterocyclic compound, 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, molecular formula is C4H8ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[00664] Synthesis of compound 1-94. To a 20-mL sealed microwave tube containing compound 112.5 (120 mg, 0.27 mmol, 1.00 equiv), 1 -methyl- lH-pyrazol-4-amine hydrochloride (77.7 mg, 0.58 mmol, 2.10 equiv) in 5 mL of isopropanol was added 0.02 mL of hydrochloric acid (4 M in dioxane) at room temperature. The reaction mixture was heated on microwave for 2.5 h at 140 C and resulting solids were collected by filtration. Crude collected was purified via flash column chromatography to give 72.2 mg (53%) of compound 1-94 as a off- white solid. LCMS (ES, m/z): 498 [M+H]+. 1H NMR(400MHz, <-DMSO): delta 8.94 (s, IH), 7.80 (s, IH), 7.46 (s, IH), 5.75-5.60 (s, IH), 4.65 (s, 2H), 34.08-3.95 (m, IH), 3.80 (s, 3H), 3.59 (t, 4H), 2.85 (s, 2H), 2.52 (s, 4H), 2.30-2.22 (m, IH), 2.10 (d, 2H), 1.92 (d, 2H), 1.55-1.32 (m, 4H), 1.28 (s, 6H). These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-pyrazol-4-amine hydrochloride, its application will become more common.