Adding a certain compound to certain chemical reactions, such as: 17635-45-9, name is 4-Pyrazol-1-yl-phenylamine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17635-45-9, SDS of cas: 17635-45-9
The title compound was prepared according to Scheme 7. To a stirred solution of 4- (i//-pyrazol-l~yl)anilme (CAS Number 17635-45-9, 0.5 g, 3.140 mmol) in chloroform (25 mL) was added K2CO3 (1.3 g, 9.422 mmol) at ambient temperature and the reaction mixture was cooled to 0-5 ¡ãC. Thiophosgene (0.73 g, 6.281 mmol) was added the reaction mixture at 0-5 ¡ãC. The resulting reaction mixture was stirred at ambient temperature for 3 h and then poured into water (15 mL). Tire obtained mixture was neutralized by NaHCCb and extracted with EtOAc (2 x 100 mL). The combined organic phase was dried over NaiSOg filtered and concentrated under reduced pressure yielding l-(4-isothiocyanatophenyl)-lii-pyrazole (compound 20.2; 0.56 g, 2.785 mmol). LCMS: Method A, 3.379 min MS: ES+ 202.1 (M+l).
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