Reference of 852227-86-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 852227-86-2 as follows.
Example 42 3-Bromo-5-(3-cyano-2-methyl-5-oxo-7-propyl-1,4,5,6,7,8-hexahydro-quinolin-4-yl)-2-(2,5-dimethyl-2H-pyrazol-3-ylmethoxy)-N,N-dimethyl-benzenesulfonamide A mixture of the compound described in example 41a (153 mg), potassium carbonate (125 mg), and 5-chloromethyl-1,3-dimethyl-1H-pyrazole (55 mg) in DMF (1.4 ml) was heated at 60 C. for 3 h. The mixture was diluted with 1N hydrochloric acid and extracted with ethyl acetate. The organic layer was dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by preparative HPLC (Method B), then purified by chromatography on aluminum oxide using ethyl acetate as eluent.Yield: 51 mg. MS-ESI: [M+H]+=616.2/618.2; anal. HPLC: Rt=18.40 min. (method 2)
According to the analysis of related databases, 852227-86-2, the application of this compound in the production field has become more and more popular.