Reference of 1018446-95-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1018446-95-1 name is tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(1) tert-butyl 4-[({4-[(2-chlorophenoxy)methyl]pyridin-2-yl}carbonyl)amino]-1H-pyrazole-1-carboxylate To a solution of 4-[(2-chlorophenoxy)methyl]pyridine-2-carboxylic acid (2.64 g) obtained in Example 119(2) in tetrahydrofuran (50 mL) was added oxalyl chloride (1 mL) at room temperature, and then N,N-dimethylformamide (1 drop) was added. The mixture was stirred at room temperature for 40 min and tetrahydrofuran was evaporated under reduced pressure. The residue was dissolved in N,N-dimethylacetamide (50 mL). This solution was added dropwise to a solution of tert-butyl 4-amino-1H-pyrazole-1-carboxylate (2.01 g) synthesised in the above-mentioned (1a) in N,N-dimethylacetamide (50 mL), which was placed in advance in a different pear shape flask. The mixture was stirred at room temperature for 3 hr. Water was added, and the precipitated solid was collected by filtration and washed with water and hexane to give a gray solid (3.73 g, 87%). 1H NMR (300 MHz, DMSO-d6) delta ppm 1.60 (s, 9H) 5.45 (s, 2H) 6.97-7.06 (m, 1H) 7.19-7.25 (m, 1H) 7.28-7.37 (m, 1H) 7.50 (dd, J=1.51, 7.91 Hz, 1H) 7.73 (dd, J=1.60, 4.99 Hz, 1H) 8.15 (s, 1H) 8.24 (d, J=0.75 Hz, 1H) 8.58 (s, 1H) 8.77 (d, J=4.90 Hz, 1H) 11.28 (s, 1H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, and friends who are interested can also refer to it.