Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows., category: pyrazoles-derivatives
Step c: NaH (33.08 g (19.85, 60percent), 1.5 eq) was washed with hexane, dry DMF (500 ml) was added drop wise under N2 atmosphere and stirred well. A solution of 3-(trifluoromethyl)- 1 H-pyrazole (75 g, 550 mmol) in DMF (125 ml) was added drop wise under N2 atmosphere. Then a solution of 4-methoxylbenzyl chloride (86.3 g, 550 mmol, 1 eq) in DMF (125 ml) was added drop wise and the overall reaction mixture was allowed to stir for 12 h at room temperature. On completion of the reaction, reaction contents were poured into ice water (500 ml) and the product was extracted with ethyl acetate (2 * 400 ml). The ethyl acetate layer was washed with 2N HCI (2x200ml). Then the contents were dried over sodium sulfate and concentrated under reduced pressure. Obtained crude was purified by silica gel column chromatography with 10percent ethyl acetate/Hexane to yield the required product as a brown colored liquid (98 g, 70percent yield).
According to the analysis of related databases, 20154-03-4, the application of this compound in the production field has become more and more popular.