Application of 1260243-04-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1260243-04-6, name is Ethyl 5-amino-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a stirred mixture of 3.2 G (20 MMOL) of ethyl 5-amino-1 H-PYRAZOLE-4-CARBOXYLATE in 95 mL of CH212 AT-10¡ãC, 24 mL of isoamyl nitrite (180 MMOL) were added during 30 minutes. The mixture was stirred two hours at 100¡ãC and, after cooling, it was concentrated under reduced pressure (first 10 mmHg then 0.1 mmHg). The residue was dissolved in ethyl acetate and the resulting solution washed with NA2S205, HCI (1N) and water. Organic phase was separated, dried over Na2SO4, filtered and concentrated under reduced pressure to give a brown solid that was purified by column chromatography, eluting with 30percent ethyl acetate in hexane to give 4.11 G (75percent) of the title compound as a yellow solid. 1 H-NMR (DMSOD6), diagnostic signals (ppm): 13.71 (s, 1H), 8.25 (s, 1H), 4.19 (q, 2H), 1.26 (t, 3H) [M+H] + =267
The synthetic route of Ethyl 5-amino-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.