Synthetic Route of 1191616-45-1, The chemical industry reduces the impact on the environment during synthesis 1191616-45-1, name is 4-(4-Bromophenyl)-1-methyl-1H-pyrazole, I believe this compound will play a more active role in future production and life.
Compound 11c (1.4g, 5.0mmol),1-(4-Bromophenyl)-1-methyl-1H-pyrazole(1.2g, 5.0mmol), catalyst Pd(dba)2 (144mg, 0.25mmol), tri-tert-butylphosphine (101mg, 0.5mmol), sodium tert-butoxide (576mg, 6.0mmol) were dissolved in toluene (50ml) The temperature was raised to 100C and the reaction was stirred for 12 hours. The reaction was detected by TLC, and directly concentrated by column chromatography to obtain 1.4g of off-white solid with a yield of 63.1%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(4-Bromophenyl)-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.