Adding a certain compound to certain chemical reactions, such as: 36650-74-5, name is 1H-Pyrazole-3-carbonitrile, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36650-74-5, Product Details of 36650-74-5
General procedure: A mixture of cyanopyrazole 8 or 11 (0.05 mol), NaN3 (4.23 g, 0.065 mol), triethylamine hydrochloride (8.94 g, 0.065 mol), and toluene (150 ml) was refluxed for 10 h in the case of compound 9 or 8 h in the case of compound 12. The reaction mixture was cooled, stirred, and diluted with 2 (200-500 ml) until complete dissolution of the precipitate. The aqueous layer was separated and acidified with HCl to 1-2. The precipitate that formed was filtered off, washed with cold water, and air-dried. In the case of compound 12, the filtrate was additionally extracted with EtOAc (350 ml), and the organic layer was dried over anhydrous Na2SO4. The solvent was removed under vacuum, providing a second crop of the product. Both precipitates were combined and air-dried. 5-(1-Pyrazol-3(5)-yl)tetrazole (9). Yield 5.37 g (79%), decomp. temp. 272-274C (EtOH). IR spectrum, nu, cm-1: 3379 (s), 3222 (s), 3125 (s), 2975 (m), 2870 (m), 2757 (m), 2637 (s), 2520 (m), 1871 (vs), 1614 (s), 1456 (s), 1347 (w), 1223 (m), 1196 (m), 1068 (s), 1034 (s), 942 (m), 922 (m), 782 (s), 750 (s), 709 (m), 608 (m). Mass spectrum, m/z: 136 [M]+. Found, %: C 35.24; H 2.96; N 61.42. 4H4N6. Calculated, %: C 35.30; H 2.96; N 61.74.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.