Synthetic Route of 741717-63-5,Some common heterocyclic compound, 741717-63-5, name is Ethyl 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate, molecular formula is C13H11F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To ethyl l-phenyl-3- (trifluoromethyl) -lH-pyrazole-4- carboxylate (20.0 g, 70.36 itimol) was added ethylenediamine (188.2 H-L, 2815 mmol) . The mixture was heated to reflux for 5 hours, cooled to room temperature, and concentrated in vacuo, and the residue was azeotroped several times with toluene to give N- (2-aminoethyl) -l-phenyl-3- (trifluoromethyl) -IH- pyrazole-4-carboxamide (20.84 g, 99%) as a tan solid: 1H NMR (400 MHz, DMSO-de) delta 1.77 (bs, 2H), 2.68 (t, 2H, J = 6.5 Hz), 3.23 (q, 2H, J = 6.2 Hz), 7.47 (m, IH), 7.60 (m, 2H), 7.83 (m, 2H), 8.28 (m, IH), 9.11 (m, IH); m/z (APCI pos) 299.0 (100%) [M+H] .
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate, its application will become more common.