In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 497832-99-2 as follows. HPLC of Formula: C5H4BrF3N2
[1,1 ?-bis(diphcnylphosphino)ferrocene]dichloropalladium(II), complex with dichloromethane (0.64 g, 0.87 mmol) was added to a mixture of 4-bromo-1-methyl-3-(trifluoromethyl)-IH- pyrazole (2.0 g, 8.7 mmol), 2-fluoro-4-(4,4,5 ,5-tetramethyl- 1,3 ,2-dioxaborolan-2-yl)aniline (2.1 g, 8.7 mmol) and Na2CO3 (1.8 g, 17.4 mmol) in 1,4-dioxane (20 mL) and water (4 mL).The reaction mixture was stirred under nitrogen atmosphere at 120 C for 12 h. After cooling to room temperature the reaction mixture was filtered, concentrated in vacuo and the residue was purified by silica gel chromatography (petroleum ether/EtOAc3:1 to 1:1) to give the title compound (1.2 g, 55%) as a light yellow solid. LCMS MIZ (M+H) 260.
According to the analysis of related databases, 497832-99-2, the application of this compound in the production field has become more and more popular.