Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 27258-33-9, name is 1-Methyl-1H-pyrazole-5-carbaldehyde, A new synthetic method of this compound is introduced below., name: 1-Methyl-1H-pyrazole-5-carbaldehyde
B); With ligand (S)-2-piperidinyl-1,1,2-triphenylethanol and diethylzinc at -10 C In a 20 ml vial 50 mg (0.21 mmol) 2-aminoethyl-dithienyl-borinate and 9.3 mg (0.025mmol) of ligand (S)-2-piperidinyl-1,1,2-triphenylethanol (10 mol%) is placed. The vial is closed and flushed with argon. Dry toluene (2 mL) is added and the vial is placed in a cooling bath of -10 C. Diethylzinc (0.7 mL, 0.7 mmol, 2M solution in toluene) and 25 mul (0.25 mmol) 2-methyl-2H-pyrazole-3-carbaldehyde is added and the reaction mixture is stirred for at least 12 h at -10 C. Work-up is conducted as described in Example 2a affording the title compound (24 mg, 51%) in 70% ee.
The synthetic route of 27258-33-9 has been constantly updated, and we look forward to future research findings.