Application of 175137-46-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 175137-46-9 name is 5-Cyclopropyl-1H-pyrazol-3-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Intermediate 172-Chloro-N-(5-cvclopropyl-lH-pyrazol-3-yl)-5-nitropyrimidin-4-amine; A mixture of 2,4-dichloro-5-nitropyrimidine (2 g) and S-cyclopropyl-lH-pyrazol-S-amine (2 g) in acetonitrile (20 mL) with diisopropylethylamine (2 mL) was stirred at room temperature for 24 hours, The resulting mixture was concentrated, and the resulting residue was separated by silica gel column (etaexane/Ethyl acetate) to afford 2.1 g desired product. MS (electrospray): 281 (M+l) for Ci0H9ClN6O2.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Cyclopropyl-1H-pyrazol-3-amine, and friends who are interested can also refer to it.