These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 17635-45-9, its application will become more common.
Some common heterocyclic compound, 17635-45-9, name is 4-Pyrazol-1-yl-phenylamine, molecular formula is C9H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 4-Pyrazol-1-yl-phenylamine
[0183] A mixture of intermediate 33 (0.10 g, 0.28 mmol) and 4-pyrazol-l-yl-phenylamine (50 mg, 0.31 mmol) in acetic acid (3 mL) was sealed in a microwave reaction tube and irradiated with microwave at 130 ¡ãC for 15 min. After cooling to room temperature, the cap was removed and the mixture concentrated. The residue was taken up in water (20 mL) and neutralized with 10percent NaOH solution until solid precipitated. The brown solid was filtered and then purified by HPLC. The corrected fractions were combined and poured into saturated NaHCO3 solution (30 mL). The combined aqueous layers were extracted with EtOAc (2 x 30 mL) and the combined organic layers washed with brine, dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated and the resulting solid dissolved in minimum amount of EtOAc and hexanes added until solid precipitated. After filtration, the title compound was obtained as a white solid (15 mg, 11percent).[0184] 1H NMR (500 MHz, DMSO-d6): delta 1.12 (s, 9H), 2.15 (s, 3H), 6.49 (t, J= 2.2 Hz, IH), 7.50-7.55 (m, 2H), 7.58 (s, IH), 7.62 (d, J= 9.1 Hz, 2H), 7.68 (d, J= 1.3 Hz, IH), 7.77 (d, J= 9.1 Hz, 2H), 7.96 (s, IH), 8.11 (s, IH), 8.13-8.16 (m, IH), 8.33 (d, J= 2.5 Hz, IH), 8.64 (s, IH), 9.17 (s, IH). MS (ES+): m/z 478 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 17635-45-9, its application will become more common.