In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 151049-87-5 as follows. SDS of cas: 151049-87-5
Dissolve YC042 (100mg, 0.4mmol) and 1-methyl-3-bromo-1H-pyrazole (129mg, 0.8mmol) in DME, add 1.6mL of 2M sodium carbonate aqueous solution, evacuate and introduce nitrogen, and add catalyst Pd (dppf) 2Cl2-CH2Cl2 (16mg). After vacuuming again, nitrogen was passed through, refluxed at 95 C overnight, diluted with water, extracted with ethyl acetate, and the organic phase was dried over anhydrous sodium sulfate. YC043 (24 mg).
According to the analysis of related databases, 151049-87-5, the application of this compound in the production field has become more and more popular.