Electric Literature of 26621-44-3,Some common heterocyclic compound, 26621-44-3, name is 3-Nitro-1H-pyrazole, molecular formula is C3H3N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-Nitro-lH-pyrazole (3 g, 26.5 mmol, 1 eq) , 3-chloro-l- methoxy-2-propanol (3.92 g, 31.9 mmol, 1.2 eq) , potassium iodide (5 mg, cat.), and cesium carbonate (17.2 g, 53.1 mmol, 2 eq) were mixed in 1,4-dioxane (18 ml). The mixture was subjected to microwave irradiation at 1200C for 30 min. The mixture was diluted with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate, filtered, and concentrated in vacuo. The residue was purified with silica gel column chromatography using 10-60% ethyl acetate in hexane as an eluent to give 2.74 g of the title compound (51%) as a yellow oil. [M+H] calc’d for C7HnN3O4202, found 202.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Nitro-1H-pyrazole, its application will become more common.