Adding a certain compound to certain chemical reactions, such as: 578008-32-9, name is tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 578008-32-9, Application In Synthesis of tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate
To a 20 mL vial was added tert-butyl (1R,3s,55)-3-((7-chloro-1,6-naphthyridin-5- yl)amino)-8-azabicyclo[3.2.ljoctane-8-carboxylate (474.6 mg, 1.22 mmol), tert-butyl 3-amino-S -methyl- 1H-pyrazole- 1 -carboxylate (289 mg, 1.46 mmol), chloro [2- (dicyclohexylphosphino)-3 ,6-dimethoxy-2?-4?-6?-tri- (58 mg, 0.073 mmol), and cesium carbonate (517 mg, 1.59 mmol). The vial was sealed with a rubber septum and the atmosphere was flushed with nitrogen. Dioxane (6.10 mL) was then added via syringe, and the septum was quickly replaced with a white cap. The reaction mixture was heatedto 110 C and stirred for 26 h and cooled to RT. The suspension was diluted with water and brine and extracted with EtOAc (4 x 20 mL). The combined organic fractions were dried over sodium sulfate, filtered, and concentrated to afford a brown foamy solid which was used directly in the next step. (m/z): [M+Hj calcd for C29H39N704 550.31, found550.8.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate, other downstream synthetic routes, hurry up and to see.