2075-46-9, name is 4-Nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 2075-46-9
MC825_SC14 Step 1-IS08149-051 1 -Methyl-4-nitro-1 H-pyrazole Procedure: To a solution of 4-nitro-1 H-pyrazole (5 g, 44.2 mmol) in dry acetonitrile (100 mL), cesium carbonate (28.8 g, 88.4 mmol) and iodomethane (4.1 mL, 66.3 mmol) are added and heated to 70C for 2 h. The reaction mixture is concentrated and the residue is taken in ethylacetate, washed with water (2 chi 75mL), brine, dried over MgS04 and concentrated to get the product. Yield: 53 % (3 g, yellow solid). LCMS: (Method A) 128.0 (M+H), RT. 1.3 min, 99.4 % (Max), 98.6 % (254 nm). 1H NMR (400 MHz, DMSO-d6): delta [ppm] 8.83 (s, 1H), 8.22 (s, 1 H), 3.90 (s, 3H).
The synthetic route of 2075-46-9 has been constantly updated, and we look forward to future research findings.