Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Safety of 4-Iodo-1-methyl-1H-pyrazole
To a solution of 4-iodo-1-methyl-1H-pyrazole (5.0 g, 24 mmol) in N,N-dimethylformamide (20 mL) was added tert-butyl prop-2-enoate (9.23 g, 72.0 mmol), triethylamine (2.91 g, 28.8 mmol), Pd(OAc)2 (538 mg, 2.40 mmol) and P(o-Tol)3 (1.46 g, 4.80 mmol). The resulting mixture was heated overnight at 110 C. under nitrogen. The reaction was concentrated, and the resulting residue was purified by flash column chromatography (1:3 ethyl acetate/petroleum ether) to provide tert-butyl (2E)-3-(1-methyl-1H-pyrazol-4-yl)prop-2-enoate as a light yellow oil (3.9 g, 74%). LCMS (ESI): [M+H]+=209.0.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.