Synthetic Route of 25016-20-0,Some common heterocyclic compound, 25016-20-0, name is 1-Methyl-1H-pyrazole-3-carboxylic acid, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(2,3-dichlorophenyl)(5-aminoindol-1-yl)methanone (40 mg, 0.13 mmol, 1.0 equiv.), 1-A-1H-pyrazole-3-carboxylic acid (17 mg, 0.134 mmol, 1.05 equiv.), HATU (54 mg, 0.14 mmol, 1.1 equiv.),DIPEA (18 mg, 0.14 mmol, 1.1 equiv.) was dissolved in an appropriate amount of DCM and stirred at room temperature for 6 to 8 hours. The TLC monitors the reaction in real time. anti-After completion, the reaction solution was diluted with 2N HCl, and extracted with three portions of ethyl acetate. The organic phase was combined and then dissolved with water and saturated NaHCO3.Wash with liquid, saturated NaCl solution, and dry the organic layer with anhydrous NaSO4.Distilled under reduced pressure to obtain a crude product,Purified by silica gel column to obtain N-(1-(2,3-Dichlorobenzoyl)porphyrin-5-yl)-1-methyl-1H-pyrazole-3-carboxamide (40 mg, yield: 73.9%).
The synthetic route of 25016-20-0 has been constantly updated, and we look forward to future research findings.