Application of 116008-52-7,Some common heterocyclic compound, 116008-52-7, name is 4-Amino-1H-pyrazole-3-carboxylic acid, molecular formula is C4H5N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Amino acid 4 (2 g, 0.0157 mol) wassuspended in absolute EtOH (20 ml). SOCl2 (1.17 ml,1.92 g, 0.0161 mol) was added dropwise to the suspension.The mixture was heated under reflux for 12 h untilhomogenization. A cherry-colored solution formed. Thesolvent was evaporated to dryness under reduced pressureon the rotary evaporator. The solid residue was dried in avacuum desiccator to constant weight. Yield 3.0 g (99%),pink solid, mp 114-115C. 1H NMR spectrum (400 MHz, DMSO-d6), delta, ppm (J, Hz): 10.22 (4, br. s, NH, +NH3);8.03 (1H, s, -3 pyrazole); 4.28 (2, q, J = 7.0,OCH2H3); 1.30 (3, t, J = 7.1, OCH2H3). 13C NMRspectrum (101 MHz, DMSO-d6), delta, ppm: 160.5; 133.7;127.3; 116.6; 60.8; 14.1. Found, m/z: 178.05868 [M+Na]+.C6H9N3NaO2. Calculated, m/z: 178.05870.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Amino-1H-pyrazole-3-carboxylic acid, its application will become more common.