Adding a certain compound to certain chemical reactions, such as: 180207-57-2, name is 2-(1H-Pyrazol-4-yl)ethanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 180207-57-2, Quality Control of 2-(1H-Pyrazol-4-yl)ethanol
A solution of 2-(1H-pyrazol-4-yl)ethan-1-ol (3.00 g, 26.75 mmol, 1.00 equiv), SEM-Cl (7.00 mL, 43.18 mmol, 1.61 equiv) and Cs2CO3 (13.00 g, 39.89 mmol, 1.49 equiv) in N,N-dimethylformamide (20 mL) was stirred for 3 h at room temperature. When LCMS indicated most of starting material was converted into the desired product, the resulting solution was concentrated and diluted with 150 mL of dichloromethane, washed with 3×50 mL of brine, dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was purified by a silica gel column eluting with DCM/MeOH (10:1) to afford 2.6 g of the title compound as yellow oil.
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