Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 119022-51-4, name is 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one, A new synthetic method of this compound is introduced below., Safety of 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3(2H)-one
Example 2: Preparation of 2-(1 -methyl-5-trifluoromethyl-1 H-pyrazol-3-yloxy)-thiazole- 5-sulfonic acid (2-methoxy-pyridin-4-ylmethyl)-amide (Table I, example I-4) Example 2.1 : Preparation of 2-(1-methyl-5-trifluoromethyl-1 H-pyrazol-3-yloxy)-thiazole 1-Methyl-5-trifluoromethyl-1 H-pyrazol-3-ol (5.1 g) in dry DMF (50 ml) under nitrogen was treated at 00C with sodium hydride (0.82 g). After the initial effervescence ceased 2-bromothiazol (5 g) and Kl (4.4 g) were added. The mixture was stirred for 23 h at1400C, the solvent was removed by rotary evaporation and the residue was purified by flash column chromatography on silica gel (cyclohexan/ethyl acetate) to yield the title compound as yellow oil (4.94 g). 1H-NMR (CDCI3): d= 3.98 (s, 3H), 6.6 (s, 1 H), 6.9 (s, 1 H), 7.3 ppm (s,1 H)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.