Related Products of 133228-21-4,Some common heterocyclic compound, 133228-21-4, name is N,N-Dimethyl-1H-pyrazole-1-sulfonamide, molecular formula is C5H9N3O2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of S1 (25.3 g, 144 mmol) in THF (200 mL) at -78 C was added dropwise 1.6 M n-butyllithium in hexane (99 ml, 159 mmol). After 30 min, EtI (12.8 mL, 159 mmol) was added dropwise. The reaction mixture was stirred at -78 C for 30 min and allowed to room temperature. After 1 h, the stirring became difficult by formation of white precipitates. THF (200 mL) was added dropwise to give yellow solution. The stirring was continued for 2 h. Then, the mixture was poured into saturated NaHCO3 aq. (600 mL), and extracted with EtOAc (400 mL x2), and the extract was dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (n-hexane/EtOAc,100:0 to 30:70, v/v) to afford S2 (19.8 g, 68%) as colorless liquid.1H NMR (300 MHz, CDCl3) d 1.30 (3H, t, J = 7.8 Hz), 2.94 (2H, dd, J = 15.0, 7.5 Hz), 3.03 (6H, s), 6.13 (1H, br s), 7.55 (1H, br s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route N,N-Dimethyl-1H-pyrazole-1-sulfonamide, its application will become more common.