Discovery of 71229-85-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-ethyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 71229-85-1, name is 4-Bromo-1-ethyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 71229-85-1, Product Details of 71229-85-1

In a RBF previously equipped with a magnetic stirrer and nitrogen balloon was taken 4- bromo-1 -ethyl-1 H-pyrazole (2.15 g, 12.33 mmol) in THF (15 ml) and the mixture was cooled at -78 C. n-BuLi (2.5 M in THF, 22.4 ml, 13.56 mmol) was added drop-wise to the reaction mixture and it was stirred at same temperature for 2 h. 5-nitro-2- phenoxybenzaldehyde (commercially available, 3.0 g 12.33 mmol) was dissolved in THF (5 ml) and the solution was added drop-wise in to reaction mixture at -78 C. The reaction mixture was stirred at -78 C for 2 h and then allowed to reach room temperature and stirred for 12 h. The reaction mixture was quenched with ammonium chloride solution (50 ml) and extracted with EtOAc (2 x 100 ml). The combined organic layer was washed with brine (100 ml) and dried over sodium sulphate and the solvent removed under reduced pressure to obtain 2 g of the crude title compound that that was used in the next step without further purification. MS (ES+) m/z 340 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-ethyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.