Reference of 118430-73-2, These common heterocyclic compound, 118430-73-2, name is 3-(tert-Butyl)-1-methyl-1H-pyrazol-5-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 4: Synthesis of compound A-6Activation of 10 g (38.2 mmol) of compound A-5 is achieved by treatment with thionyl chloride (17 mL) at 70 C for 3 h. The reaction mixture is cooled to room temperature and excess thionyl chloride is removed under reduced pressure. The crude acid chloride is dissolved in DCM (100 mL) and added to a solution of 5.84 g (38.2 mmol) of 5-tert-butyl-2-methyl-2H-pyrazol-3-ylamine and N,N-diisopropylethylamine (13.27 mL) in DCM (150mL). The reaction is stirred at room temperature for 16 h. The solvent is removed under reduced pressure. The residue is dissolved with DCM (300 mL) and washed with saturated aqueous NaHC03 solution (300 mL). The organic layer is separated and washed with brine (300 mL). and dried over Na2S04, filtered and the filtrate is concentrated under reduced pressure. The crude product is purified by column chromatography (200 g silica, eluent: DCM, 0-20% ethyl acetate). The resulting solid is washed sparingly with cyclohexane, then dried under vacuum to afford 12.145 g of compound A-6 as a pink powder. Yield 80%; ES-MS: m z 398/400 [M+H]; 1H-NMR (400 MHz, CHLOROFORM-d) delta rhorhoetaiota 1.30 (9 H, s), 1.62 (6 H, s), 3.78 (3 H, s), 6.22 (1 H, s), 7.48 – 7.68 (2 H, m), 7.70 – 7.96 (2 H, m), 8.88 (1H, s).
The synthetic route of 118430-73-2 has been constantly updated, and we look forward to future research findings.