Adding a certain compound to certain chemical reactions, such as: 100114-57-6, name is 3-Cyclopropyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100114-57-6, category: pyrazoles-derivatives
In a 50 mL round-bottomed flask was added 3-cyclopropyl-1H-pyrazole (2.0 g, 18 mmol), K2C03 (5.1 g, 37 mmol) and 5-bromo-2-fluorobenzonitrile (3.7 g, 18 mmol) in DMF (15 mL) to give a yellow suspension.Then reaction mixture was stirred at rt for overnight under nitrogen atmosphere. The excess DMF was distilled from the mixture at reduced pressure, and the residue was diluted with water (50 mL). The aq layer wasextracted with EtOAc (3 x 50 mL). The combined organic layers were washed with brine (1 x 25 mL). The organic solution was dried over Na2SO4, filtered and concentrated at reduced pressure to give crude product. The crude material was added to a silica gel column and was eluted with 2%-i 0% of ethyl acetate-petether to afford a white color solid (3.7 g, i2 mmol). ?H NMR (400 MHz, CD3OD) oe ppm 8.05 (d, J= 2 Hz, iH), 7.84 (d, J=2 Hz, iH), 7.76 (dd, J= 2, 8.8 Hz, iH), 7.70 (d, J= 8.8 Hz, iH), 6.22 (d, J 2 Hz, iH),2.00 (m, iH), i.00 (m, 2H), 0.86 (m, 2H).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.