Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1145-01-3, name is 3,5-Diphenyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Product Details of 1145-01-3
A solution of ethyl 3,5-diphenyl-1-hydropyrazole (0.20 mmol ), tert-butyl alpha-diazoacetoacetate ( 0.25 mmol) was added in a 25 mL Schrocker tube at room temperature,[Cp * RhCl2] 2 (0¡¤01 mmol), AgSbF6 (0.04 mmol) and tetrahydrofuran (2.00 mL) were added and argon was bubbled through argon for 2 minutes. Tighten the lid. Stir at 60 C for 24 hours. The reaction was stopped and concentrated under reduced pressure to give a crude product. The column was finally rinsed with a mixture of petroleum ether and ethyl acetate and subjected to rapid column chromatography (silica gel column) to give the corresponding nitrogen-containing fused heterocyclic compound (60 mg of white solid, 84% yield).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.