Electric Literature of 20154-03-4,Some common heterocyclic compound, 20154-03-4, name is 3-(Trifluoromethyl)-1H-pyrazole, molecular formula is C4H3F3N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1: Preparation of 1-(4-nitro-ph 1H-pyrazole1 -fluoro-4-nitro benzene (4.14 g, 29.4 mmol) was added slowly to a solution of 3- trifluoromethylpyrazole (2 g, 14.7 mmol) and anhydrous potassium carbonate (6 g, 44.1 mmol) in D F at room temperature.The reaction mixture was then heated at 110C overnight then cooled to RT. The reaction mixture was diluted with water then extracted with ethyl acetate (2 x). The combined organic layers were washed with water and brine, then dried over sodium sulfate, filtered and concentrated to give the title compound as a beige solid (3.3 g, 87.4%). TLC: Ethylacetate/Hexane (3/7): Rf : 0.85. 1H N R (CDCI3; 400 MHz): delta 8.38 (dd, J = 9.1 Hz, 2H), 8.10 (d, J = 2.4 Hz, 1 H), 7.94 (dd, J = 9.1 Hz, 2H), 6.83 (d, J = 2.5 Hz, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(Trifluoromethyl)-1H-pyrazole, its application will become more common.