Related Products of 162758-35-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 162758-35-2 name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a suspension of carboxylic acid in CH2Cl2 (0.1 M) at rt. was added (COCl)2(3 eq) and a catalytic amount of DMF (1 drop). The mixture was then stirred for 1 h and concentratedin vacuo. The resultant crude acid chloride was dissolved in CH2Cl2 then DIPEA (6 eq) and the amine(1.5 eq) were added. The mixture was stirred at rt. for a further 16 h, washed with H2O three times,dried over Mg2SO4, filtered, and concentrated in vacuo. The resultant crude oil was then purified byflash chromatography to give the amide product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, and friends who are interested can also refer to it.