Related Products of 175137-46-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows.
17/18D. trans-Methyl 2-(4-(5-cyclopropyl-lH-pyrazol-3-ylamino)pyrrolo[l,2-f][l,2,4]triazin-2-yl)cyclopentanecarboxylate. trans-Methyl 2-(4-oxo-3,4-dihydropyrrolo[l,2-f][l,2,4]triazin-2- yl)cyclopentanecarboxylate hydrochloride (450 mg, 1.51 mmol) was dissolved in POCl3 (10 mL, 107 mmol) and heated to 85 0C for 1.5 h, then at 100 0C for an additional 4.5 h. The reaction was cooled to rt and concentrated in vacuo, co- evaporating with toluene several times. NMP (6 mL) was added to the residue, and the reaction was heated to 80 0C before a solution of 5-cyclopropyl-lH-pyrazol-3- amine (922 mg, 7.49 mmol) dissolved in NMP (6 mL) was slowly injected. The reaction was stirred overnight at 80 0C, then cooled to rt. EtOAc (250 mL) was added, and the reaction was washed with water (2 x 150 mL) and brine (150 mL). The organic layer was dried (MgSO4), filtered, and concentrated in vacuo. The compound was purified by silica gel flash chromatography (0-40% 90: 10: 1 [CH2Cl2ZMeOHZcOnC NH4OH]ZCH2Cl2), followed by trituration with 1: 1 CH2Cl2ZHeX to give 17/18D (260 mg, 50%). 17/18D had an analytical HPLC retention time = 2.15 min (Waters XBridge 4.6 x 50 mm, 5-95% aqueous acetonitrile over 5 min containing 10 mM ammonium acetate) and a LCZMS M+ + 1 = 367.
The chemical industry reduces the impact on the environment during synthesis 5-Cyclopropyl-1H-pyrazol-3-amine. I believe this compound will play a more active role in future production and life.