Application of 138786-86-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 138786-86-4 name is Methyl 4-nitro-1H-pyrazole-3-carboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(2); To dried methanol (830ml) was carefully added sodium metal (6.71g), and the mixture was ice-cooled after sodium pieces are completely dissolved. Thereto were added compound (1) (43.61g) and then methyl iodide (43.64ml), and the mixture was stirred at 60?70C for 4 hours. After concentrated in vacuo, to the residue was chloroform and the solution was washed with aqueous saturated sodium bicarbonate solution and saturated brine, and dried. After removal of the solvent, the residue was purified with silica gel column chromatography (hexane:ethyl acetate=4:1?1:1) to give compound (2) (17.0g) as a yellow oil, and compound (3) (26.8g) as a colorless powder. Compound (2): APCI-MS (m/e): 186 (M+H)+ 1HNMR(500MHz/DMSO-d6 (ppm):3.95(s,3H),4.00(s,3H),8.37(s,1H) Compound (3): APCI-MS (m/e): 186 (M+H)+ 1HNMR(500MHz/DMSO-d6)delta(ppm):3.94(s,3H),4.00(s,3H),8.95(s,1H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-nitro-1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.