Electric Literature of 180207-57-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 180207-57-2 as follows.
A mixture of thionyl chloride (6.318 g, 53.55 mmol) and 2-(1H-pyrazol-4-yl)ethan-1-ol (2.0 g, 17.85 mmol) was heated to 70C for 15 minutes. The reaction mixture was concentrated under reduced pressure, the residue was triturated with ethanol/diethyl ether to the title compound (2.3 g, 98%) as an off-white solid. (0690) LC-MS (method 9): f = 1.61 min; m/z = 131.06 (M+H-).
According to the analysis of related databases, 180207-57-2, the application of this compound in the production field has become more and more popular.