Some common heterocyclic compound, 876343-24-7, name is 1-Ethyl-1H-pyrazol-4-amine, molecular formula is C5H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C5H9N3
Example 7lambdar-(l-ethyl-lH-pyrazol-4-yl)-2-[5-(6,7-dimethoxyquinazolin-4-yloxy)-3-methoxypyridin-2- yl]acetamideDiisopropylethylamine (0.263 ml) and 2-(7-azabenzotriazol-l-yl)- 1,1,3,3-tetramethyluronium hexafluorophosphate(V) (0.186 g) were added in turn to a stirred mixture of 2-[5-(6,7-dimethoxyquinazolin-4-yloxy)-3-methoxypyridin-2-yl]acetic acid(0.14 g), 4-amino-lH-l-ethylpyrazole (0.072 g) and DMF (1.5 ml) and the resultant mixture was stirred at ambient temperature for 18 hours. The resultant mixture was concentrated by evaporation and the residue was purified by preparative etaPLC using a Waters ‘Xterra’ reversed-phase column (5 microns silica, 19 mm diameter, 10 mm length) using decreasingly polar mixtures of water (containing 0.2percent ammonium carbonate) and acetonitrile as eluent. There was thus obtained the title compound (0.085 g); 1H NMR: (DMSOd6) 1.33 (t, 3H), 3.78 (s, 2H), 3.8 (s, 3H), 3.99 (s, 3H), 4.0 (s, 3H), 4.06 (q, 2H), 7.41 (d, IH), 7.54 (d, IH), 7.58 (s, IH), 7.86 (s, IH), 8.11 (d, IH), 8.59 (s, IH), 10.13 (br s, IH); Mass Spectrum: M+H+ 465.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 876343-24-7, its application will become more common.