Adding a certain compound to certain chemical reactions, such as: 83725-05-7, name is N-(5-Methyl-1H-pyrazol-3-yl)acetamide, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 83725-05-7, HPLC of Formula: C6H9N3O
4.1.2 N-(5-methyl-4-nitro-1H-pyrazol-3-yl)acetamide (3) Compound 2 (4.5g, 32?mmol) was dissolved in 50?mL concentrated H2SO4, and the solution was cooled to -5?C. Concentrated HNO3 (2.3?mL, 32?mmol) was added dropwise and the mixture was maintained at -5?C for 3?h. The reaction mixture was added to 150?mL ice water slowly, and then white solid appeared with stirring. The solid washed by water and dried to give pure 3 (4.65?g, 25?mmol, 72% yield). Mp: 240-241?C; 1H NMR (400?MHz, DMSO-d6) delta 10.24 (s, 1H), 2.45 (s, 3H), 2.13 (s, 3H).
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