Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 69843-13-6, name is 1-Methyl-1H-pyrazol-4-amine, A new synthetic method of this compound is introduced below., name: 1-Methyl-1H-pyrazol-4-amine
Example 4.082- [ [5-Fluoro-2- [(l-methylpyrazol-4-yl)aminol -4-pyridyll amino I -N-methyl-benzamide A mixture of l-methylpyrazol-4-amine (41.7 mg, 0.43 mmol), 9,9-dimethyl-4,5- bis(diphenylphosphino)xanthene (41.4 mg, 0.07 mmol), bis(dibenzylideneacetone)palladium (32.7 mg, 0.057 mmol), sodium tert-butoxide (51.5 mg, 0.54 mmol), and 2-[(2-chloro-5-fluoropyridin-4-yl)amino]-N-methylbenzamide (100 mg, 0.36 mmol) was suspended in dioxane (3 mL). The mixture was heated at 150C for 30 minutes in a microwave reactor and then allowed to cool to room temperature. The mixture was loaded onto an SCX column and the product eluted first with MeOH and then with a 7M solution of NH3 in MeOH. Fractions containing product were combined and evaporated. The residue was purified by preparative HPLC and fractions containing product were combined and evaporated to afford example 4.08 (51.2 mg, 42% yield); 1H NMR spectrum: (300 MHz, DMSO) delta 2.78 (3H, d), 3.77 (3H, s), 6.66 – 6.68 (IH, m), 7.07 – 7.10 (IH, m), 7.31 (IH, s), 7.47 – 7.56 (2H, m), 7.69 – 7.72 (IH, m), 7.84 (IH, s), 7.91 – 7.92 (IH, m), 8.51 (IH, s), 8.64 (IH, q), 10.08 (IH, d); Mass spectrum: m/z (ESI+) (M+H)+ = 341.04.
The synthetic route of 69843-13-6 has been constantly updated, and we look forward to future research findings.