Related Products of 5334-40-7, The chemical industry reduces the impact on the environment during synthesis 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, I believe this compound will play a more active role in future production and life.
A stirred solution of S-83 (1.00 g, 6.36 mmol) in THF (10 mL) taken in a round- bottom flask was charged with Et3N (1.3 mL, 9.55 mmol) and DPPA (2.62 g, 9.55 mmol) at room temperature. The reaction mixture was stirred for 6 h at room temperature under nitrogen atmosphere. At this time, t-butanol (10 mL) was added and refluxed for 6 h under nitrogen atmosphere. When TLC showed complete consumption of starting material, the reaction mixture was diluted with the water (10 mL) and extracted with EtOAc (2 ¡Á 10 mL). The combined organic layers were washed with water (10 mL). The organic layers were dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel using 0? 50percent EtOAc in hexanes as eluent to afford S-91 (0.20 g, 14percent, AMRI lot IN-SKY-C-110) as an off-white solid. The compound was characterized by UPLC analysis. MS-UPLC (MM) m/z 127.2 [M? ]-
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