In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 16034-46-1 as follows. name: 1-Methyl-1H-pyrazole-5-carboxylic acid
To a solution of 1-methyl-1H-pyrazole-5-carboxylic acid (46.6 mg, 0.37 mmol, 1.3 equiv) in DMF (1 ml) were added HATU (140 mg, 0.37 mmol, 1.3 equiv), DIEA (147 mg, 1.14 mmol, 4.0 equiv), and 7-(5-ethyl-1,2,4-oxadiazol-3-yl)-3,4-dihydro-2H-1-benzopyran-4- amine hydrochloride (80 mg, 0.28 mmol, 1.0 equiv). The mixture was stirred overnight and purified by Prep-HPLC with the following conditions: (2-AnalyseHPLC- SHIMADZU(HPLC-10)): Column, XBridge Prep C18 OBD Column, 5 mum,19*150mm; mobile phase, water (10MMOL/L NH4HCO3) and ACN (34.0% ACN up to 47.0% in 8 min); Detector, UV 220nm. This purification resulted in 170 mg (90%) of N-[6-(5-ethyl-1,2,4- oxadiazol-3-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]-1-methyl-1H-pyrazole-4-carboxamide as a white solid. LRMS (ES) m/z 354 (M+H).
According to the analysis of related databases, 16034-46-1, the application of this compound in the production field has become more and more popular.