Electric Literature of 1192-21-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, This compound has unique chemical properties. The synthetic route is as follows.
Step 1: A clean 100 L cylindrical reaction vessel was charged with THF (13 kg) then (S)-1-(2-((tert-butyldimethylsilyl)oxy)-1-(4-chloro-3-fluorophenyl)ethyl)-4-(2-(methylsulfonyl)pyrimidin-4-yl)pyridin-2(1H)-one (I, 5 kg) and 1-methyl-1H-pyrazol-5-amine (1.1 kg) were added sequentially with medium agitation followed by THF (18 kg). The mixture was cooled to ?35¡ã C. and to the resulting thin slurry was added slowly a THF solution of LiHMDS (17.4 kg, 1.0 M) at a rate that maintained the internal temperature below ?25¡ã C. After the addition was completed, the reaction was held between ?35 and ?25¡ã C. for 20 min and monitored by HPLC. If the HPLC result indicated ?98.5percent conversion, additional LiHMDS (0.34 kg, 1.0 M, 0.05 mol percent) was added slowly at ?35¡ã C. The reaction was quenched slowly at the same temperature with H3PO4 solution (4.4 kg of 85percent H3PO4 and 15 kg of water) and the internal temperature was kept below 30¡ã C. The reaction was diluted with EtOAc (18 kg) and the phases separated, the organic layer was washed with H3PO4 solution (1.1 kg of 85percent H3PO4 and 12 kg of water) followed by a second H3PO4wash (0.55 kg of 85percent H3PO4 and 12 kg of water). If 1-methyl-1H-pyrazol-5-remained, the organic layer was washed again with H3PO4 solution (0.55 kg of 85percent H3PO4 and 12 kg of water). Finally the organic layer was washed sequentially with water (20 kg) and a NaCl and NaHCO3 solution (2 kg of NaCl, 0.35 kg of NaHCO3 and 10 kg of water). After the phase separation, residue water in organic solution was removed through an azeotropic distillation with EtOAc to <0.5percent (by KF) and then solution was concentrated to 20-30 L under a vacuum below 50¡ã C. The solvent was then swapped to MeOH using 35 kg of MeOH and then concentrated to between 20 and 30 L for the next step. The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-5-amine. I believe this compound will play a more active role in future production and life.